5/15/2023 0 Comments Presence of pacemaker icd 10Citation2021), and exhibited antiviral properties (Zorofchian Moghadamtousi et al. Furthermore, other studies reported that curcumin suppressed the release of inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, IL-6, and IL-8 (Babaei et al. Some previous studies showed that curcumin inhibited the production of bradykinin and prostaglandins through its anti-inflammatory effects (Koeberle et al. Citation2018) therefore, we believe that foods containing polyphenols are effective against the common cold.Ĭurcumin, a type of polyphenol, has long been used in traditional medicine to treat skin conditions due to its anti-inflammatory properties (Hatcher et al. ![]() Among food components, polyphenols have been reported to exhibit several immunomodulatory and anti-inflammatory properties (Yahfoufi et al. Modulating these pathways is therefore anticipated to reduce the symptoms of viral upper respiratory tract infections (also known as cold symptoms). In contrast, systemic symptoms, such as fever, myalgia, and headache, are caused by the release of cytokines from dendritic cells, neutrophils, and macrophages in response to the activation of Toll-like receptors (Eccles Citation2009). Local symptoms, such as sneezing, runny nose, nasal congestion, and coughing, are caused by the production of bradykinin and prostaglandins in the nasal epithelium. There are two pathways that cause cold symptoms after viral infection. According to research, cold syndrome is characterized by the onset of symptoms such as headache, sneezing, chills, and sore throat, followed by nasal discharge, nasal congestion, coughing, and fatigue (Jackson et al. The term ‘common cold’ is ill-defined both subjectively and objectively, and it is frequently used to refer to the manifestations of the cold syndrome, such as sinusitis, pharyngitis, laryngitis, tonsillitis, and otitis media (Eccles Citation2009). Local symptoms in the nose and throat are noted in mild cases, while systemic symptoms with fever and muscle pain are observed in severe cases (Eccles Citation2005, Citation2009). The common cold is a viral upper respiratory tract infection caused by some viruses, such as rhinovirus, adenovirus, coronavirus, enterovirus, influenza virus, parainfluenza virus, and respiratory syncytial virus (Wine and Alper Citation2012). Consumption of highly bioavailable curcumin, TS-P1 or CR-033P (150 mg/day), for 12 weeks reduced the number of days for which common cold symptoms persisted in healthy Japanese adults. The cumulative number of days for which common cold symptoms persisted was significantly lower in the TS-P1 and CR-033P groups than that in the placebo group. Ninety-four subjects completed the study, and the per protocol set included 30 subjects in the placebo group, 32 subjects in the TS-P1 group, and 33 subjects in the CR-033P group. Immunity parameters, inflammatory parameters, liver function parameters, and physical examination results were additional outcomes. ![]() The cumulative number of days for which common cold symptoms persisted was set as the primary outcome. ![]() ![]() For 12 weeks, each group consumed the four capsules that were given to them daily. Using a computerized random number generator, each subject was randomly assigned to one of the following three groups: TS-P1, CR-033P, or placebo ( n = 33 per group). A randomized, double-blind, placebo-controlled study was conducted from November 2021 to May 2022 on 99 healthy Japanese adults. This study aimed to investigate the effects of 12-week consumption of highly bioavailable curcumin (150 mg/day of Theracurmin Super or Theracurmin ) on common cold symptoms, immune function, and inflammatory markers.
0 Comments
Leave a Reply. |